| 2023-11 |
Targeting FLT3-TAZ signaling to suppress drug resistance in blast phase chronic myeloid leukemia |
Molecular Cancer
|
| 2023-03 |
Reprogramming anchorage dependency by adherent-to-suspension transition promotes metastatic dissemination |
Molecular Cancer
|
| 2023-02 |
Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant |
Experimental & Molecular Medicine
|
| 2023-01 |
Emphasis on Adipocyte Transformation: Anti-Inflammatory Agents to Prevent the Development of Cancer-Associated Adipocytes |
Cancers
|
| 2023-01 |
Short-term carcinogenicity study of N-methyl-N-nitrosourea in FVB-Trp53 heterozygous mice |
PLoS ONE
|
| 2021-11 |
Sensitivity to tumor development by TALEN-mediated Trp53 mutant genes in the susceptible FVB/N mice and the resistance C57BL/6 mice |
Laboratory Animal Research
|
| 2021-10 |
mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Muller glia |
ELIFE
|
| 2021-06 |
EVI1 activates tumor-promoting transcriptional enhancers in pancreatic cancer |
NAR Cancer
|
| 2021-05 |
C1qa deficiency in mice increases susceptibility to mouse hepatitis virus A59 infection |
JOURNAL OF VETERINARY SCIENCE
|
| 2021-04 |
Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts |
NATURE COMMUNICATIONS
|
| 2021-01 |
Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation |
DIABETES
|
| 2020-11 |
Synergistic antitumor activity of a DLL4/VEGF bispecific therapeutic antibody in combination with irinotecan in gastric cancer |
BMB REPORTS
|
| 2020-11 |
Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex |
CELL DEATH AND DIFFERENTIATION
|
| 2020-09 |
Impaired AKT signalin and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer |
ONCOGENE
|
| 2020-09 |
Classifying the Linkage between Adipose Tissue Inflammation and Tumor Growth through Cancer-Associated Adipocytes |
MOLECULES AND CELLS
|
| 2020-09 |
Differential manifestation of ocular phenotypes in TALEN-mediated p19arf knockout FVB/N and C57BL/6J mouse lines |
GENES & GENOMICS
|
| 2020-08 |
Bee venom inhibits the proliferation and migration of cervical-cancer cells in an HPV E6/E7-dependent manner |
BMB REPORTS
|
| 2020-08 |
Divergence of the PIERCE1 expression between mice and humans as a p53 target gene |
PLOS ONE
|
| 2020-06 |
Effect of pierce1 on colorectal cancer |
EXPERIMENTAL ANIMALS
|
| 2020-06 |
O-GlcNAcylation on LATS2 disrupts the Hippo pathway by inhibiting its activity |
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
|
| 2020-06 |
DNAJC14 Ameliorates Inner Ear Degeneration in the DFNB4 Mouse Model |
Molecular therapy Methods & clinical development.
|
| 2020-03 |
The position of the target site for engineered nucleases improves the aberrant mRNA clearance in in vivo genome editing |
SCIENTIFIC REPORTS
|
| 2019-08 |
Sexually dimorphic leanness and hypermobility in p16Ink4a/CDKN2A-deficient mice coincides with phenotypic changes in the cerebellum |
SCIENTIFIC REPORTS
|
| 2019-07 |
Effect of EI24 expression on the tumorigenesis of Apc(Min)/+ colorectal cancer mouse model |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
|
| 2019-06 |
Phenotyping analysis of p53 knockout mice produced by gene editing and comparison with conventional p53 knockout mice |
GENES & GENOMICS
|
| 2019-05 |
Cardioprotective role of APIP in myocardial infarction through ADORA2B |
CELL DEATH & DISEASE
|
| 2019-03 |
The R229Q mutation of Rag2 does not characterize severe immunodeficiency in mice |
SCIENTIFIC REPORTS
|
| 2019-03 |
Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia |
AMERICAN JOURNAL OF HUMAN GENETICS
|
| 2019-01 |
Transgenic overexpression of human LY6K in mice suppresses mature T cell development in the thymus |
ONCOLOGY LETTERS
|
| 2018-12 |
CRISPR/Cas9-mediated knockout of CD47 causes hemolytic anemia with splenomegaly in C57BL/6 mice |
Laboratory Animal Research
|
| 2018-12 |
CRISPR/Cas9-mediated generation of a Plac8 knockout mouse model |
Laboratory Animal Research
|
| 2018-12 |
Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing |
Laboratory Animal Research
|
| 2018-12 |
Disruption of the Tff1 gene in mice using CRISPR/Cas9 promotes body weight reduction and gastric tumorigenesis |
Laboratory Animal Research
|
| 2018-12 |
CRISPR/Cas9-mediated knockout of Rag-2 causes systemic lymphopenia with hypoplastic lymphoid organs in FVB mice |
Laboratory Animal Research
|
| 2018-11 |
A myo-inositol diet for lung cancer prevention and beyond |
JOURNAL OF THORACIC DISEASE
|
| 2018-09 |
Successful development of squamous cell carcinoma and hyperplasia in RGEN-mediated p27 KO mice after the treatment of DMBA and TPA |
Laboratory Animal Research
|
| 2018-07 |
Telomerase Reverse Transcriptase Contains a BH3-Like Motif and Interacts with BCL-2 Family Members |
MOLECULES AND CELLS
|
| 2018-06 |
Differences between immunodeficient mice generated by classical gene targeting and CRISPR/Cas9-mediated gene knockout |
TRANSGENIC RESEARCH
|
| 2018-05 |
CRISPR-Cas9-mediated generation of obese and diabetic mouse models |
EXPERIMENTAL ANIMALS
|
| 2018-04 |
Multiple sgRNAs with overlapping sequences enhance CRISPR/Cas9-mediated knock-in efficiency |
EXPERIMENTAL AND MOLECULAR MEDICINE
|
| 2018-02 |
Hexokinase 2 is a molecular bridge linking telomerase and autophagy |
PLOS ONE
|
| 2018-02 |
Oncogene-induced senescence mediated by c-Myc requires USP10 dependent deubiquitination and stabilization of p14ARF |
CELL DEATH AND DIFFERENTIATION
|
| 2017-12 |
Upstream signalling of mTORC1 and its hyperactivation in type 2 diabetes (T2D) |
BMB REPORTS
|
| 2017-12 |
Emerging Paradigm of Crosstalk between Autophagy and the Ubiquitin-Proteasome System |
MOLECULES AND CELLS
|
| 2017-08 |
Human telomerase reverse transcriptase (hTERT) positively regulates 26S proteasome activity |
JOURNAL OF CELLULAR PHYSIOLOGY
|
| 2017-03 |
Establishment of a Conditional Transgenic Mouse Model Recapitulating EML4-ALK-Positive Human Non?Small Cell Lung Cancer |
JOURNAL OF THORACIC ONCOLOGY
|
| 2017-02 |
Expanding the Genetic Code of Mus musculus. |
NATURE COMMUNICATIONS
|
| 2016-12 |
Overexpression of Telomerase Reverse Transcriptase Induces Autism-like Excitatory Phenotypes in Mice |
MOLECULAR NEUROBIOLOGY
|
| 2016-11 |
Functional characterization of EI24-induced autophagy in the degradation of RING domain E3 ligases |
AUTOPHAGY
|
| 2016-09 |
Adenylyl cyclase 3 haploinsufficiency confers susceptibility to diet-induced obesity and insulin resistance in mice |
SCIENTIFIC REPORTS
|
| 2016-09 |
Telomerase reverse transcriptase induces basal and amino acid starvation-induced autophagy through mTORC1 |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
|
| 2016-08 |
Ablation of human telomerase reverse transcriptase (hTERT) induces cellular senescence in gastric cancer through a galectin-3 dependent mechanism |
ONCOTARGET
|
| 2016-08 |
Extracellular superoxide dismutase ameliorates house dust mite-induced atopic dermatitis-like skin inflammation and inhibits mast cell activation in mice |
EXPERIMENTAL DERMATOLOGY
|
| 2016-07 |
CHIP-mediated degradation of transglutaminase 2 negatively regulates tumor growth and angiogenesis in renal cancer |
ONCOGENE
|
| 2016-06 |
Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert(-/-) mice |
TRANSLATIONAL PSYCHIATRY
|
| 2016-06 |
PIERCE1 is critical for specification of left-right asymmetry in mice. |
SCIENTIFIC REPORTS
|
| 2016-02 |
Developing genetically engineered mouse models using engineered nucleases: Current status, challenges, and the way forward |
Drug Discovery Today: Disease Models
|
| 2015-11 |
Reduced expression of EI24 confers resistance to gefitinib through IGF-1R signaling in PC9 NSCLC cells |
LUNG CANCER
|
| 2015-10 |
SOD3 Variant, R213G, Altered SOD3 function, leading to ROS-mediated inflammation and damage in multiple organs of premature aging mice. |
ANTIOXIDANTS & REDOX SIGNALING
|
| 2014-08 |
Generation of knockout mice using engineered nucleases |
METHODS
|
| 2014-08 |
Perturbation of NCOA6 Leads to Dilated Cardiomyopathy |
CELL REPORTS
|
| 2014-01 |
Extracting Extra-Telomeric Phenotypes from Telomerase Mouse Models |
YONSEI MEDICAL JOURNAL
|
| 2014-01 |
Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases |
GENOME RESEARCH
|
| 2013-12 |
EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-kappa B activity |
Oncotarget
|
| 2013-10 |
Ei24, a Novel E2F Target Gene, Affects p53-independent Cell Death upon Ultraviolet C Irradiation |
JOURNAL OF BIOLOGICAL CHEMISTRY
|
| 2013-08 |
Clinical implications of antitelomeric drugs with respect to the nontelomeric functions of telomerase in cancer |
ONCOTARGETS AND THERAPY
|
| 2013-04 |
Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation |
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
|
| 2013-04 |
Stabilization of p21 (Cip1/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage response |
CELL DEATH AND DIFFERENTIATION
|
| 2013-03 |
Inactivation of Max Interacting Protein 1 Induces Renal Cilia Disassembly through Reduction in Levels of Intraflagellar Transport 20 in Polycystic Kidney. |
JOURNAL OF BIOLOGICAL CHEMISTRY
|
| 2013-03 |
Loss of Extracellular Superoxide Dismutase Induces Severe IL-23-Mediated Skin Inflammation in Mice |
JOURNAL OF INVESTIGATIVE DERMATOLOGY
|
| 2013-01 |
Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene |
CELL CYCLE
|
| 2013-01 |
Knockout mice created by TALEN-mediated gene targeting |
NATURE BIOTECHNOLOGY
|
| 2012-12 |
Mouse Genetics: Catalogue and Scissors |
BMB REPORTS
|
| 2012-12 |
Poly(ADP-ribosyl)ation of p53 induces gene-specific transcriptional repression of MTA1 |
ONCOGENE
|
| 2012-11 |
Acceleration of Gastric Tumorigenesis Through MKRN1-Mediated Posttranslational Regulation of p14ARF |
JOURNAL OF THE NATIONAL CANCER INSTITUTE
|
| 2012-11 |
Ei24-deficiency attenuates protein kinase Cα signaling and skin carcinogenesis in mice |
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
|
| 2012-07 |
Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis |
NATURE COMMUNICATIONS
|
| 2012-06 |
Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis |
JOURNAL OF CLINICAL INVESTIGATION
|
| 2012-01 |
Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade |
EMBO REPORTS
|
| 2011-11 |
Mxi1 regulates cell proliferation through insulin-like growth factor binding protein-3 |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
|
| 2011-08 |
Transgenic overexpression of p23 induces spontaneous hydronephrosis in mice |
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
|
| 2010-12 |
Pierce1, a Novel p53 Target Gene Contributing to the Ultraviolet-Induced DNA Damage Response |
Cancer Research
|
| 2010-11 |
Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody |
Blood
|
| 2010-10 |
An Analysis of an Interactome for Apoptosis Factor, Ei24/PIG8, Using the Inducible Expression System and Shotgun Proteomics |
Journal of Proteome Research
|
| 2010-08 |
In vitro and in vivo Anti-tumor Effects of Oriental Herbal Mixtures |
Food Science and Biotechnology
|
| 2010-07 |
Hdm2 negatively regulates telomerase activity by functioning as an E3 ligase of hTERT |
ONCOGENE
|